Isaac was born in Guatemala to a Cuban father and a Guatemalan mother. However he was raised in Miami, Florida. He is also of French and Israeli origins. Before he became an actor, he played lead guitar and sang vocals for his band “The Blinking Underdogs”. He graduated from Juilliard School in 2005. Isaac’s first major film role was Joseph in the film The Nativity Story. He also had a small role in All About the Benjamins and the Che Guevara biopic Guerrilla.